# Public Data Sets
ICA Cohorts comes front-loaded with a variety of publicly accessible data sets, covering multiple disease areas and also including healthy individuals.
| Data set | Samples | Diseases/Phenotypes | Reference |
| -------------------- | ------------------------------------------------- | ------------------------------------------------------------------------------------------------------- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |
| 1kGP-DRAGEN | 3202 WGS: 2504 original samples plus 698 relateds | Presumed healthy | [DRAGEN reanalysis of the 1000 Genomes Dataset](https://aws.amazon.com/blogs/industries/dragen-reanalysis-of-the-1000-genomes-dataset-now-available-on-the-registry-of-open-data/) |
| DDD | 4293 (3664 affected), *de novos* only | Developmental disorders | [McRae et al., Nature 19:1194-1196](https://www.nature.com/articles/nature21062) |
| EPI4K | 356, *de novos* only | Epilepsy | [Epi4K Consortium, Nature 501:217-221](https://www.nature.com/articles/nature12439) |
| ASD Cohorts | 6786 (4266 affected), *de novos* only | Autism Spectrum disorder | Iossifov et al. Neuron 74:285-299;
Iossifov et al. Nature 498:216-221;
O'Roak et al. Nature 485:246-250;
Sanders et al. Nature 485:237-241;
Sanders et al. Neuron 87:1215-1233;
De Rubeis et al. Nature 515:209-215
|
| De Ligt *et al.* | 100, *de novos* only | Intellectual disability | [De Ligt et al., N Engl J Med 367:1921-1929](https://www.nejm.org/doi/full/10.1056/NEJMoa1206524) |
| Homsy *et al.* | 1213, *de novos* only | Congenital heart disease (HP:0030680) | [Homsy et al., Science 350:1262-1266](https://www.science.org/doi/10.1126/science.aac9396) |
| Lelieveld *et al.* | 820, *de novos* only | Intellectual disability | [Lelieveld et al., Nature Neuroscience19:1194-1196](https://www.nature.com/articles/nn.4352) |
| Rauch *et al.* | 51, *de novos* only | Intellectual disability | [Rauch et al., Lancet 380:1674-1682](https://www.sciencedirect.com/science/article/pii/S0140673612614809) |
| Rare Genomes Project | 315 WES (112 pedigrees) | Various | |
| TCGA | ca. 4200 WES, ca. 4000 RNAseq | 12 tumor types | |
| GEO | RNAseq | Auto-immune disorders, incl. asthma, arthritis, SLE, MS, Crohn's disease, Psoriasis, Sjögren's Syndrome | For GEO/GSE study identifiers, please refer to the in-product list of studies |
| | RNAseq | Kidney diseases | For GEO/GSE study identifiers, please refer to the in-product list of studies |
| | RNAseq | Central nervous system diseases | For GEO/GSE study identifiers, please refer to the in-product list of studies |
| | RNAseq | Parkinson's disease | For GEO/GSE study identifiers, please refer to the in-product list of studies |
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