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Compare Cohorts

Up to four cohorts can be compared. Once comparisons are created, they are saved in the Comparisons left-navigation tab of the Cohorts module.

Attribute Comparison, Survival Summary, and Survival Comparison

  1. 1.
    Select Cohorts from the left-navigation panel.
  2. 2.
    Select 2 to 4 cohorts already created. If you have not created any cohorts, See Create a Cohort documentation.
  3. 3.
    Click Compare Cohorts in the right-navigation panel.
  4. 4.
    Note you are now in the Comparisons left-navigation tab of the Cohorts module.
  5. 5.
    In the Charts Section, if the COHORTS item is not displayed, click the gear icon in the top right and add Cohorts as the first attribute and click Save.
  6. 6.
    The COHORTS item in the charts panel will provide a count of subjects in each cohort and act as a legend for color representation throughout comparison screens.
  7. 7.
    For each clinical attribute category, a bar chart is displayed. Use the gear icon to select attributes to display in the charts panel.

Attribute Comparison

  1. 1.
    Select the Attributes tab, as it is not selected by default.
  2. 2.
    Attribute categories are listed and can be expanded using the down-arrows next to the category names. The categories available are based on cohorts selected. Categories and attributes are part of the ICA Cohorts metadata template that map to each Subject.
  3. 3.
    For example, use the drop-down arrow next to Vital status to view sub-categories and frequencies across selected cohorts.

Survival Summary

  1. 1.
    Select the Survival Summary tab.
  2. 2.
    Attribute categories are listed and can be expanded using the down-arrows next to the category names.
  3. 3.
    Select the drop-down arrow for Therapeutic interventions.
  4. 4.
    In each subcategory there is a sum of the subject counts across select cohorts.
  5. 5.
    For each cohort, designated by a color, there is a Subject count and Median survival (years) column.
  6. 6.
    Type Malignancy in the Search Box and an auto-complete dropdown suggests three different attributes.
  7. 7.
    Select Synchronous malignancy and the results are automatically opened and highlighted in orange.

Survival Comparison

  1. 1.
    Click Survival Comparison tab.
  2. 2.
    A Kaplan-Meier Curve is rendered based on each cohort.
  3. 3.
    P-Value Displayed at the top of Survival Comparison indicates whether there is statistically significant variance between survival probabilities over time of any pair of cohorts (CI=0.95).
When comparing two cohorts, the P-Value is shown above the two survival curves. For three or four cohorts, P-Values are shown as a pair-wise heatmap, comparing each cohort to every other cohort.
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Cohort Analysis
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Cohorts Data in ICA Base
Last modified 1mo ago